PolyNucleotides are the next big thing in AESTHETIC MEDICINE

What are they?

Polynucleotides are long chains of nucleotides, which are the building blocks of DNA and RNA. In recent years, polynucleotides have been studied for their potential applications in regenerative medicine, particularly tissue engineering.

One approach is to use polynucleotides to deliver therapeutic genes to cells in a tissue. By encapsulating genes within a polynucleotide carrier, researchers can target specific cells and deliver therapeutic genes directly to them. This approach has shown promise in animal studies for treating various diseases and conditions, including wound healing, liver regeneration, and neurodegenerative diseases.

Another approach is to use polynucleotides as a scaffold material for tissue engineering. For example, polynucleotides can be engineered to form complex 3D structures, which can be seeded with cells and used as a scaffold for tissue regeneration. This approach has shown promise in regenerating skin, bone, and cartilage tissue.

One of the advantages of using polynucleotides in regenerative medicine is their biocompatibility and biodegradability. In addition, polynucleotides are naturally occurring and can be easily broken down by enzymes in the body, which reduces the risk of adverse reactions and toxicity.

In summary, polynucleotides have great potential in regenerative medicine to deliver therapeutic genes and as a scaffold material for tissue engineering.

Polynucleotides and Skin Rejuvenation

Polynucleotides have also been studied for potential applications in aesthetic medicine, particularly skin rejuvenation. Polynucleotides can be used as a skin revitalizing agent, as they have been shown to stimulate fibroblast and elastin production.

Fibroblasts are cells that produce collagen, elastin, and other extracellular matrix proteins that provide structural support to the skin. Elastin is a protein that provides elasticity and resilience to the skin. As we age, the production of fibroblasts and elastin decreases, leading to the loss of skin firmness and elasticity, which results in wrinkles and sagging skin.

Polynucleotides can stimulate the production of fibroblasts and elastin, promoting skin rejuvenation and reducing the appearance of wrinkles and fine lines. They do this by activating certain growth factors and cytokines, which stimulate the proliferation of fibroblasts and the synthesis of elastin. We love the Phil Art and Philart Eye by Croma

In addition to stimulating fibroblast and elastin production, polynucleotides also have antioxidant properties, which protect the skin from oxidative stress and damage caused by UV radiation and environmental pollutants.

Polynucleotides can be administered through injections or topical application. Injections are typically used to treat specific areas of the face, such as the forehead, around the eyes, and the nasolabial folds. Topical applications can be used as part of a daily skincare routine to promote overall skin health and rejuvenation.

A course of 3 treatments is recommended over a period of 6-8 weeks

Polynucleotides and use on the skin under the eyes and dark circles-

Polynucleotides have shown potential in addressing skin ageing concerns around the eyes, such as under-eye wrinkles, fine lines, and dark circles. The skin under the eyes is thin and delicate, and as we age, it can become thinner and lose elasticity, leading to wrinkles and fine lines. Additionally, dark circles can develop due to a combination of factors, including thinning skin, poor circulation, and pigmentation changes.

If you look at the images, you can see my eyes having this treatment – I must believe!

Polynucleotides promote tissue repair and regeneration, increase collagen synthesis, and reduce inflammation, all of which can help address skin ageing concerns around the eyes.

Firstly, polynucleotides promote tissue repair and regeneration by stimulating the proliferation of fibroblasts, which are the cells responsible for producing collagen and other extracellular matrix proteins necessary for maintaining skin elasticity and firmness. By promoting collagen synthesis, polynucleotides can help reduce wrinkles and fine lines, resulting in a more youthful appearance.

Secondly, polynucleotides have anti-inflammatory properties, which can be beneficial in addressing dark circles. Inflammation can cause blood vessels to dilate and leak, leading to dark circles. By reducing inflammation, polynucleotides can help to improve circulation and reduce the appearance of dark circles.

In addition to their direct effects on the skin, polynucleotides can enhance the effects of other treatments for skin ageing concerns around the eyes. For example, combining polynucleotides with other dermal fillers, such as hyaluronic acid, can help improve the skin’s volume and hydration, resulting in a smoother and more youthful appearance. Additionally, polynucleotides can be combined with micro-needling or laser treatments, which can help improve the penetration and efficacy of the polynucleotides.

Overall, polynucleotides have shown potential in addressing skin ageing concerns around the eyes, such as under-eye wrinkles, fine lines, and dark circles.- I live in HOPE !!!!! And results of treatment 2 today.

Polynucleotides and Rosacae / Inflammation

Polynucleotides have anti-inflammatory properties that are potentially effective in treating inflammatory skin conditions such as rosacea.

Rosacea is a chronic inflammatory skin condition that typically affects the face, causing redness, visible blood vessels, and pimple-like bumps. The exact cause of rosacea is not fully understood, but it is believed to involve an abnormal immune response and inflammation in the skin.

Polynucleotides have been shown to reduce inflammation in the skin by inhibiting the production of pro-inflammatory cytokines and chemokines. In addition, polynucleotides can stimulate the production of anti-inflammatory cytokines, which help to reduce inflammation and promote healing.

Polynucleotides can be administered through topical application or injection. Topical applications can be used in a daily skincare routine to help reduce inflammation and improve the skin’s overall appearance. Injections can treat specific areas of the face affected by rosacea.

In addition to their anti-inflammatory properties, polynucleotides can promote tissue regeneration, which can help repair damage caused by inflammation and improve the skin’s overall health.

In summary, polynucleotides can potentially treat inflammatory skin conditions such as rosacea. Their anti-inflammatory properties can help to reduce inflammation and promote healing, while their ability to promote tissue regeneration can help to repair damage caused by inflammation

Polynucleotides and hair restoration

Hair loss is a common problem that affects both men and women and can be caused by various factors, including genetics, hormonal imbalances, stress, and ageing. While several treatments are available for hair loss, many have limited effectiveness and can be costly or invasive. As a result, polynucleotides have emerged as a potential new treatment for hair restoration, offering a promising approach for promoting hair growth and improving the overall health of the scalp.

Polynucleotides are long chains of nucleotides, which are the building blocks of DNA and RNA. They have been shown to have anti-inflammatory and antioxidant properties and the ability to stimulate cell growth and tissue repair. These properties make them potentially effective in promoting hair growth and improving scalp health.

Polynucleotides can promote hair growth by stimulating the proliferation of dermal papilla cells located at the base of hair follicles and play a crucial role in hair growth. Polynucleotides can also increase blood flow to the scalp, providing essential nutrients and oxygen to the hair follicles, promoting growth and improving the overall health of the scalp.

In addition to their direct effects on hair growth, polynucleotides can also help to repair damage to the scalp caused by factors such as inflammation, oxidative stress, and UV radiation. These factors can damage the hair follicles and inhibit hair growth, but polynucleotides can help to repair the damage and promote healthy hair growth.

Polynucleotides can be administered through injections or topical application. Injections are typically used to deliver polynucleotides directly to the scalp, stimulating hair growth and improving the hair follicles’ health. Topical applications can also be used as part of a daily hair care routine to promote hair growth and improve the overall health of the scalp.

While using polynucleotides for hair restoration is a relatively new approach, growing evidence supports its effectiveness. In a clinical study, patients who received polynucleotide injections for hair restoration showed significant improvements in hair density, thickness, and overall scalp health. Another study found that topical polynucleotide application increased hair growth in patients with androgenetic alopecia, a common form of hair loss.

One of the advantages of using polynucleotides for hair restoration is their safety and lack of side effects. Polynucleotides are naturally occurring and are biocompatible, meaning they are not likely to cause adverse reactions or toxicity. This makes them a safe and effective option for those seeking a non-invasive treatment for hair loss.

In conclusion, polynucleotides have emerged as a promising new treatment for hair restoration. Their ability to stimulate hair growth and improve the health of the scalp makes them a potentially effective and safe option for those seeking to restore hair growth and enhance the appearance of their hair.

Polynucleotides and scarring

Polynucleotides have shown potential in reducing scarring by promoting tissue repair and regeneration, reducing inflammation, and modulating the expression of growth factors and cytokines involved in wound healing.

When an injury occurs, the body initiates a complex series of events that lead to wound healing and tissue repair. This process involves inflammation, cell proliferation, extracellular matrix deposition, and tissue remodelling. However, in some cases, the wound-healing process can lead to excessive scar formation, resulting in functional impairment, aesthetic concerns, and psychological distress.

Polynucleotides promote tissue repair and regeneration, reduce inflammation, and modulate the expression of growth factors and cytokines involved in wound healing. For example, polynucleotides encourage the proliferation of fibroblasts, which are the cells responsible for producing collagen and other extracellular matrix proteins necessary for tissue repair and regeneration. Additionally, polynucleotides have been shown to increase the expression of growth factors such as transforming growth factor-beta (TGF-beta) and vascular endothelial growth factor (VEGF), which are important for angiogenesis, collagen synthesis, and tissue repair.

In addition to promoting tissue repair and regeneration, polynucleotides are also shown to reduce inflammation. Inflammatory cytokines such as interleukin-1 (IL-1) and tumour necrosis factor-alpha (TNF-alpha) are involved in the wound-healing process, but excessive inflammation can lead to excessive scarring. Polynucleotides have been shown to reduce the expression of these inflammatory cytokines and promote the production of anti-inflammatory cytokines such as IL-10, which can help to reduce inflammation and promote tissue healing.

Polynucleotides have also been shown to modulate the expression of growth factors and cytokines involved in the wound-healing process. For example, polynucleotides have been shown to increase the expression of matrix metalloproteinases (MMPs), enzymes that break down extracellular matrix proteins and promote tissue remodelling. Additionally, polynucleotides have been shown to reduce the expression of TGF-beta, which can contribute to excessive scar formation.

In Conclusion, Polynucleotides are versatile molecules that have shown promise in aesthetic medicine for their ability to stimulate tissue repair and regeneration, reduce inflammation, and improve skin texture and appearance. Combining polynucleotides with other aesthetic treatments can create a synergistic effect that enhances their therapeutic potential and improves treatment outcomes.

One example of combining polynucleotides with other aesthetic treatments is their combination with platelet-rich plasma (PRP) therapy for skin rejuvenation. PRP is a treatment that involves collecting a patient’s blood, processing it to concentrate the platelets and growth factors, and injecting it into the skin to promote tissue repair and regeneration. Combining PRP with polynucleotides can enhance their effects on skin rejuvenation by stimulating collagen synthesis, improving skin texture and elasticity, and reducing the appearance of fine lines and wrinkles.

Another example of combining polynucleotides with other aesthetic treatments is their use of hyaluronic acid (HA) fillers for facial rejuvenation. HA fillers are a popular treatment for restoring volume and reducing the appearance of wrinkles and folds in the face. Combining polynucleotides with HA fillers can enhance their effects by promoting tissue repair and regeneration, increasing collagen synthesis, and improving skin hydration and elasticity.

Polynucleotides can also be combined with other non-invasive aesthetic treatments, such as radiofrequency (RF) or laser therapy. RF and laser treatments stimulate collagen synthesis and promote tissue repair and regeneration. Combining polynucleotides with RF or laser therapy can enhance their effects by providing additional growth factors and promoting tissue repair and regeneration.

Finally, polynucleotides can be combined with other topical skin care treatments, such as retinoids, vitamin C, and peptides. These treatments are designed to improve skin texture, reduce the appearance of fine lines and wrinkles, and promote collagen synthesis. Combining polynucleotides with these topical treatments can enhance their effects by providing additional growth factors and promoting tissue repair and regeneration.

Combining polynucleotides with other aesthetic treatments can create a synergistic effect that enhances their therapeutic potential and improves treatment outcomes. Polynucleotides can be combined with a wide range of aesthetic treatments, including PRP therapy, HA fillers, RF or laser therapy, and topical skin care treatments.

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