Polynucleotides in Cosmetic Medicine in 2024

Polynucleotides have emerged as a cutting-edge treatment in cosmetic medicine. Their regenerative properties are increasingly popular for skin rejuvenation, particularly in sensitive areas like the periorbital (eye) region. We are still learning about polynucleotides, but their results look promising, and in my opinion, it definitely works in areas other products do not, especially under eye wrinkles. Here’s an overview of how polynucleotides work, their benefits, and why they’re gaining momentum in 2024.

What Are Polynucleotides?

Polynucleotides are natural DNA fragments derived from salmon. They possess potent regenerative properties that stimulate tissue repair and enhance skin health. Here’s a breakdown of how they work:

  1. Cell Regeneration: Polynucleotides promote the regeneration of fibroblasts (cells that produce collagen and elastin) to improve skin structure and elasticity.
  2. Hydration: They increase hydration levels within the skin, resulting in a plumper and more youthful appearance.
  3. Anti-Inflammatory: Their anti-inflammatory properties help calm irritated or sensitive skin.

How Do Polynucleotides Work in Cosmetic Treatments?

Polynucleotides are injected into the skin using fine needles or microcannulas. The procedure involves several small injections into the targeted area. Here’s how it typically works:

  1. Treatment Process:
    A numbing cream is applied to minimise discomfort.
    Polynucleotides are injected into the dermal layer using a series of fine needle injections.
  2. Areas Commonly Treated:
    Periorbital Region (Around the Eyes): Reduces dark circles, fine lines, and puffiness.
    Neck: Improves skin elasticity and reduces horizontal necklines.
    Face: Addresses overall skin laxity and hydration.
    Décolletage: Reduces fine lines and improves skin texture.
  3. Number of Treatments Required:
    Initial Series: Three sessions spaced 3-4 weeks apart are typically required for optimal results.
    Maintenance: After the initial series, maintenance treatments every 4-6 months help sustain the benefits.

Polynucleotide Science and Mechanism of Action

  1. Fibroblast Activation: Polynucleotides stimulate fibroblast activity, increasing collagen and elastin production. This improves skin firmness and elasticity.
  2. Angiogenesis Promotion: They promote angiogenesis (new blood vessel formation), improving skin oxygenation and nutrient supply.
  3. Hydration Boost: Polynucleotides attract and retain water molecules, increasing skin hydration and giving a plump, youthful appearance.
  4. Antioxidant Properties: They reduce oxidative stress, protecting the skin from free radical damage and improving overall skin health.

Common Polynucleotide Products Used in Cosmetic Medicine

  1. 5Nucleofill®: A polynucleotide-based injectable for skin rejuvenation and hydration.
  2. Rejuran®: Known as “Skin Healer,” it’s popular for periorbital treatments.
  3. Dermafocus: Created by renowned Italian manufacturer Mastelli, NEWEST can be used on the face, neck, and décolletage. A separate product —NEWEST One—designed specifically for use on the body will be available soon.

    NEWEST combines highly-purified polynucleotide technology, known as PN-HPT®, with non-crosslinked hyaluronic acid and mannitol. The mannitol has been clinically proven to reduce the degradation of hyaluronic acid by 34%g 4Plenhyage®: A versatile polynucleotide product for the face and body.

  4. Croma®: Developed by Croma Pharma, it provides skin rejuvenation through tissue regeneration and enhanced hydration.

Frequently Asked Questions About Polynucleotides in Cosmetic Medicine

  • How long do the effects of polynucleotides last?
    After the initial series of 3 treatments, results can last up to 6-9 months. Maintenance treatments contribute to extending the benefits, which are currently recommended every six months.
  • Are there any side effects or downtime associated with polynucleotide treatments?
    Minimal side effects include slight swelling or bruising at injection sites, which resolve within a few days. There is generally no significant downtime.
  • Can polynucleotides treat dark circles effectively?
    Yes, polynucleotides claim they can significantly reduce the appearance of dark circles by improving skin texture and blood circulation in the periorbital area. However, I am still researching and continually reviewing our results.
  • How soon will I see results after a polynucleotide treatment?
    Improvements in hydration and texture can be seen within 1-2 weeks. Full results, including increased firmness and reduced fine lines, are visible after the initial treatment series.
  • Can polynucleotides be combined with other treatments like Botox or fillers?
    Yes, polynucleotides can complement other treatments, such as Botox or fillers to provide comprehensive rejuvenation results. We are also trialling Exosomes.
  • Is the polynucleotide treatment suitable for all skin types?
    The treatment is generally suitable for all skin types and tones due to its regenerative and hydrating properties.
  • Do polynucleotides help with acne scars or pigmentation?
    Polynucleotides can improve skin texture and reduce the appearance of superficial acne scars by stimulating collagen production. They can also help with pigmentation by promoting skin regeneration.
  • Is the procedure painful, and how long does it take?
    The procedure is well-tolerated due to the use of numbing cream. Each session typically lasts around 30 minutes.
  • Can I wear makeup immediately after a polynucleotide treatment?
    It’s best to avoid makeup for at least 24 hours post-treatment to allow the skin to heal and absorb the product fully.
  • What is the ideal age to start polynucleotide treatments?
    Polynucleotide treatments can benefit adults of any age who seek improved skin health, hydration, and rejuvenation.

At Tracey Bell Dental and Aesthetic Clinic, we’re committed to helping you achieve your aesthetic goals with realistic expectations and professional advice.

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